May 16, 2002, 19th Annual Triangle Chromatography Symposium (TCDG)

Prediction of retention times and generic methods for high-throughput chromatography

Daria Jouravleva, Michael McBrien, Eduard Kolovanov

Abstract

In walk-up chromatography and parallel synthesis, high-throughput is the key. For these applications, generic methods have been designed to apply to as many different kinds of samples as possible. However, when the sample is not suited to the method, costly instrument down-time can result. New ACD/ChromGenius software will advise if methods are viable, and select between multiple methods where available. The poster presents physicochemical parameters used to model the chromatographic separation, and describes applied retention time and method selection algorithm.

Download the presentation in PDF format (912 Kb)