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June 25 - 29, 2006, 30th National Medicinal Chemistry Symposium 2006, Seattle, WA, USA
Efficient Chiral Screening and Purification in Support of Medicinal Chemistry
Michael McBrien1; Frank Riley2
1Advanced Chemistry Development, Inc. (ACD/Labs), 110 Yonge Street, 14th Floor, Toronto, ON. Canada. M5C 1T4.
2Separation and Purification Sciences, Discovery Technologies, Pfizer Global Research and Development, 2800 Plymouth Road, Ann Arbor, MI 48105.
Abstract
To assert that 40% of compounds under development in the pharmaceutical industry today are chiral is a conservative estimate. Oftentimes, these compounds are purified rather than being produced by chiral-specific synthesis. However, the volume of samples for purification can create a bottleneck in the discovery process. The first step in the chiral purification process is to screen numerous separation methods for selectivity at the analytical scale, followed by scale-up to preparative or semi-preprep scale. In this paper we describe how an analytical laboratory can speed up chiral method development using specialized software. The software accumulates, evaluates, and links chemical structures to chromatographic methods. This database of information can be accessed and searched to prioritize purification methods for subsequent samples thus reducing the amount of time required to collect and review data, and allowing timely delivery of results to chemists.
Download the poster in Adobe Acrobat format (171 Kb PDF file).
Relevant Product: ACD/ChromManager
Relevant Solution: Medicinal Chemistry
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