Solutions for Chromatography

There are several times in the life cycle of a chemical product that chromatographic separation is applied. In the discovery, product development, QA/QC, chiral method development, and manufacturing laboratories, the pressing need is to retrieve or develop a suitable separation method. The definition of suitability may change as the product matures from the research lab through to the production facility. In each case, ACD/Labs offers capabilities that enable the separation scientist to reduce the time it takes to arrive at the optimal separation method.

Accelerate Method Development

Poor selection of a method starting point can lead to a number of costly problems such as:

• Column destruction leading to unnecessary costs and instrument downtime while a new column is loaded and equilibrated;
• Very long retention times leading to inefficient usage of the instruments; and
• Insufficient separation and the need to run the sample again on a different method.

Software can help users select the best starting point for method development, which reduces the number of unnecessary experiments. A three-step approach is advised:

For more information on how this three-step approach accelerates chromatographic method development, click here.

Speed Chiral Purification

Since chiral chromatographic separations often require specialized method development, some analytical laboratories do thousands of injections per week investigating chiral methods for purification of samples. To learn how to speed up sample turnaround, visit here.

Select the Best Generic or Standard Method for Your Sample

In chromatography or LC/MS laboratories where high-throughput is the key, ACD/ChromGenius will choose the best generic method for your compound and suggest the retention time, thereby reducing the number of standard methods to screen before the most appropriate method is selected. ChromGenius comes with a database of built-in generic methods from which to choose, or you can train the system with your own set of generic methods. Read more...

Easily Communicate Results

Chromatographic separation is necessary in many stages of product research and development. Knowledge of previous results, even if obtained by another department, can assist with the selection of a method starting point. The creation of a corporate knowledge base, accessible over the corporate intranet can help departments easily communicate results. See examples of how Corporate Databases facilitate communication between departments.